Soluble Dietary Fibres in the Prevention of Type 2 Diabetes Mellitus

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Type 2 Diabetes Mellitus; Obesity

Treatments: Other: Polydextrose and soluble gluco fibre

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01163006

MEC 09-3-084

Details and patient eligibility

About

Controlling the glycemic impact of foodstuffs (by reducing the glycemic load of the diet by using soluble dietary fibres) may reduce the glycemic or insulinemic response. This may in turn result in a reduced inhibition of postprandial fat oxidation rate and a lower plasma triacylglycerol concentration A higher postprandial fat oxidation may result in less lipid accumulation in non-adipose tissue thereby improving insulin sensitivity and the metabolic profile in the longer term.

Enrollment: 60 estimated patients

Sex: All

Ages: 30 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Overweight men and women

Exclusion criteria

• regular smokers, athletes, diabetes mellitus

Trial design

60 participants in 4 patient groups, including a placebo group

polydextrose

Experimental group

Treatment:

Other: Polydextrose and soluble gluco fibre

soluble glucofibre

Experimental group

Treatment:

Other: Polydextrose and soluble gluco fibre

isocaloric dietary control

Placebo Comparator group

Treatment:

Other: Polydextrose and soluble gluco fibre

full caloric control

Placebo Comparator group

Treatment:

Other: Polydextrose and soluble gluco fibre