Soluble ST2 and Cardiovascular Outcome

Nanjing Medical University

Status: Enrolling

Conditions: Cardiovascular Disease

Treatments: Diagnostic Test: soluble ST2

Study type: Observational

Funder types: Other

Identifiers

NCT04460131

sST2-2019

Details and patient eligibility

About

Cardiac surgery induces hemodynamic stress on the myocardium, and this process can be associated with significant cardiovascular morbidity and mortality. Soluble suppression of tumorigenicity 2 (sST2) is biomarker of myocardial remodeling and fibrosis; however, little is known regarding their potential association with cardiovascular events. This study aimed to investigate the release of sST2 and its association with cardiovascular events undergoing cardiac surgery.

Enrollment: 500 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age ≥ 18 years
• Congenital heart disease requiring surgery
• Valvular heart disease requiring surgery
• Arrhythmia requiring surgery
• Aortic dissection requiring surgery
• Coronary heart disease requiring surgery

Exclusion criteria

• age <18 years
• pregnancy
• severe renal dysfunction (creatinine >200µmol/L)
• not capable of understanding or signing informed consent.