Somatostatin Receptor PET Imaging to Guide Radiotherapy Dose Escalation in High Risk Meningiomas. (SPIDER-MEN)

Centro di Riferimento Oncologico - Aviano

Status

Enrolling

Conditions

Meningioma

Treatments

Radiation: Dose escalation of radiation therapy, based on somatostatin receptor PET imaging

Study type

Interventional

Funder types

Other

Identifiers

NCT06830356

CRO-2024-47

Details and patient eligibility

About

High-risk meningiomas always require postsurgical radiation treatment. Recent evidence has shown that increased radiation therapy dose may be associated with increased intracranial control of disease. In order to better define the volume of radiation treatment, the addition of PET imaging with somatostatin receptor tracers adds additional information compared to encephalon MRI with MoC alone.The present study aims to investigate whether radiation treatment with higher doses than the standard and defined using PET imaging can be safe and at the same time effective in order to increase progression-free survival in high-risk meningiomas.

Enrollment

53 estimated patients

Sex

All

Ages

16+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age ≥ 16 years;
Ability to express appropriate informed consent to treatment;
Diagnosis of grade III meningioma (regardless of presence of residual) or diagnosis of recurrence of grade II meningioma (regardless of presence of residual) or first diagnosis of grade II meningioma with presence of residual;
In case of recurrence, confirmation can be either histological or radiological;
Not previous brain-level radiotherapy;
Performance status: ECOG=0-2.

Exclusion criteria

Refusal to radiation treatment (i.e., absence of signed informed consent);
Other concomitant oncologic therapies
Current pregnancy;
Grade I meningiomas or Grade II meningiomas if operated on at first diagnosis with radical resection;
Inability to perform MRI with MoC or PET.