Somesthesic Role of the Ventro-lateral Prefrontal Cortex in Speech Motor Learning (BRAVA²)

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Speech; Motor Activity

Treatments: Behavioral: Speech adaptation; Behavioral: Vibrotactile Discrimination; Other: fMRI; Behavioral: Speech production

Study type: Interventional

Funder types: Other

Identifiers

NCT04547569

38RC18.173

Details and patient eligibility

About

These studies test the hypothesis that frontal areas of the brain participate in the cortical networks involved in the somotosensory processing that happens during speech motor learning.

Full description

This work aims to study the role of sensory systems in human motor learning and specifically addresses the involvement of somatosensory cortical networks in motor learning of speech. Previous studies in the literature have highlighted the plasticity of cortical sensory networks, notably the primary and secondary somatosensory cortex and the ventral premotor cortex, during motor learning tasks. The present project focuses on the somatosensory region with connections to the sensorimotor regions of the frontal and parietal cortex. We propose to use neuroimaging (fMRI), in order to verify which areas in the prefrontal cortex are part of the sensorimotor network used in the learning of speech motor tasks in humans. Subjects will be tested in the fMRI scanner while performing either a behavioral task in which the auditory feedback of their own speech is altered or while performing a vibrotactile discrimination task.

Enrollment: 16 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Right-handed subjects
• Subjects fluent in French
• Signed informed consent
• Affiliation to or beneficiary of a Social Security scheme

Exclusion criteria

• Left-handed subjects

• Criteria for contraindications to protocol fMRI scans

• Existence of a severe general condition: cardiac, respiratory, hematological, renal, hepatic, cancerous.

• Hearing, language (including dyslexia), neurological or psychiatric disorders.

• Participation in other ongoing intervention research protocols with exclusionary period or within the previous week

• Drug treatment likely to modulate brain activity: benzodiazepines, antidepressants, neuroleptics, lithium, etc.

• Protected persons referred to in articles L1121 5 to L1121 8 of the French CSP:

  • Pregnant women, parturients, nursing mothers,
  • Persons deprived of liberty by a judicial or administrative decision,
  • Persons under psychiatric care,
  • Individuals admitted to a health or social institution for purposes other than research,
  • Minors,
  • Persons over the age of majority who are subject to a legal protection measure or who are unable to express their consent

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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16 participants in 3 patient groups

Adaptation to altered auditory feedback

Experimental group

Description:

fMRI measurement of brain activity during speech production under altered auditory feedback

Treatment:

Other: fMRI

Behavioral: Speech adaptation

Speech production

Experimental group

Description:

fMRI measurement of brain activity during normal speech production

Treatment:

Other: fMRI

Behavioral: Speech production

Vibrotactile discrimination

Experimental group

Description:

fMRI measurement of brain activity during a vibrotactile discrimination task

Treatment:

Behavioral: Vibrotactile Discrimination

Other: fMRI