Sonazoid-enhanced Ultrasound for the Detection of Colorectal Liver Metastases Less Than 2 cm

Sun Yat-sen University

Status: Unknown

Conditions: Liver Metastasis Colon Cancer

Treatments: Diagnostic Test: After sonazoid

Study type: Observational

Funder types: Other

Identifiers

NCT04686942

Sonazoid001

Details and patient eligibility

About

Preoperative chemotherapy is often used for patients with colorectal cancer liver metastasis (CLM). Many small CLMs (<=2cm) may disappear after chemotherapy, while most of these are still alive. Ultrasonography (US) is a common imaging modality for the intraoperative detection tumor. Sonazoid is new echo-contrast agent, which is more stable and sensitive for detecting of small tumor. Investigators initially this prospective study to compare the detection performance before and after using sonazoid.

Enrollment: 550 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pathology confirmed colorectal adenocarcinoma
• One or more liver metastases less than 2 cm
• Multidisciplinary team recommend to perform preoperative chemotherapy
• Have baseline EOB-MR before chemotherapy

Exclusion criteria

• Could not fulfill the criteria of no evidence of disease (NED) after hepatic resection/ablation/radiotherapy
• With other malignancies

Trial design

550 participants in 2 patient groups

Before sonazoid

Description:

US detection liver metastases before sonazoid

After sonazoid

Description:

US detection liver metastases after sonazoid

Treatment:

Diagnostic Test: After sonazoid