Sonographic Examination of Renal Function in Individuals With Long-term Spinal Cord Injury

Swiss Paraplegic Research, Nottwil

Status: Enrolling

Conditions: Spinal Cord Injuries; Renal Insufficiency

Treatments: Diagnostic Test: renal doppler sonography; Diagnostic Test: renal scintigraphy

Study type: Observational

Funder types: NETWORK; Other

Identifiers

NCT04241666

2020-01

Details and patient eligibility

About

Patients with long-term lower urinary tract dysfunction due to spinal cord injury presenting for a routine urodynamic control will be screened for inclusion and exclusion criteria. Suitable individuals providing written informed consent will undergo renal Doppler sonography and renal scintigraphy in addition to the routine examinations. Conclusions regarding renal function based on the clearance rate determined by scintigraphy (gold standard) will be compared with the conclusions based on Doppler sonography and Cystatin C clearance.

Enrollment: 51 estimated patients

Sex: All

Ages: 30+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• long-term spinal cord injury (≥10 years)
• age ≥30 years
• written informed consent

Exclusion criteria

• dementia or severe intellectual impairment
• serious internal illness
• previous or current tumor disease
• known allergy to the radioactive marker (Technetium)
• pregnancy or breastfeeding
• withdrawal of informed consent

Trial design

51 participants in 3 patient groups

normal renal function

Description:

individuals with renal clearance \>89 ml/min/1.73m²

Treatment:

Diagnostic Test: renal doppler sonography

Diagnostic Test: renal scintigraphy

mild renal insufficiency

Description:

individuals with renal clearance 60-89 ml/min/1.73m²

Treatment:

Diagnostic Test: renal doppler sonography

Diagnostic Test: renal scintigraphy

moderate renal insufficiency

Description:

individuals with renal clearance 30-59 ml/min/1.73m²

Treatment:

Diagnostic Test: renal doppler sonography

Diagnostic Test: renal scintigraphy