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SOTO: Treatment Sensitivity of Organoids to Predict Treatment Outcome

G

Guy's and St Thomas' NHS Foundation Trust

Status

Enrolling

Conditions

Head and Neck Cancer
Head and Neck Squamous Cell Carcinoma

Study type

Observational

Funder types

Other

Identifiers

NCT05400239
SOTO Study 305689

Details and patient eligibility

About

In this study, we aim to assess whether Patient Derived Organoids can be used to predict treatment sensitivity in HNSCC patients.

Full description

This is a prospective observation study to generate patient-derived organoids from patients' samples to assess treatment response and to correlate with patients' treatment outcomes and to collect preliminary data on the ability of PDOs to predict patients' treatment response and whether their radiosensitivity and chemosensitivity can be correlated with their survival outcome.

Enrollment

60 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients with head and neck squamous cell carcinoma (including oral cavity, oropharynx, paranasal sinuses, hypopharynx or larynx) undergoing curative treatment (primary surgery or radiotherapy) or presenting with recurrent or metastatic cancers
  • Age > 18 years old

Exclusion criteria

  • Patients unable to give informed consent e.g. mental disability or vulnerable adults

Trial design

60 participants in 3 patient groups

Cohort 1
Description:
Surgically resectable disease, followed by adjuvant radiotherapy +/- chemotherapy
Cohort 2
Description:
Primary radiotherapy +/- concurrent chemotherapy
Cohort 3
Description:
Recurrent or metastatic HNSCC undergoing platinum based chemotherapy +/- cetuximab

Trial documents
1

Trial contacts and locations

1

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Central trial contact

Anthony Kong; Ifigenia Vasiliadou

Data sourced from clinicaltrials.gov

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