Sound and Music for Mild Cognitive Impairment

Johns Hopkins University

Status: Completed

Conditions: Mild Cognitive Impairment

Treatments: Behavioral: A: 40 Hz music; Behavioral: C: Preferred music; Behavioral: B: 40 Hz sound

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT05064007

IRB00295386

R21AG078917 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Emerging studies in humans found that 40 Hz sound induces neural gamma oscillation and enhanced cognitive function in older adults with and without Alzheimer's Disease. We will compare a 40 Hz music intervention to both 40 Hz sound and music alone in a clinical cohort of older adults with mild cognitive impairment.

Enrollment: 52 patients

Sex: All

Ages: 50 to 95 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Community-dwelling
2. amnesia mild cognitive impairment
3. Preserved function
4. No dementia

Exclusion criteria

1. known diagnosis of schizophrenia or Parkinson's disease;
2. severe hearing impairment;
3. presence of an acute medical or psychiatric condition which would interfere with the subject's ability to follow the study protocol realistically

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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52 participants in 3 patient groups

1

Experimental group

Description:

this group will be exposed to condition A first, then B, and C

Treatment:

Behavioral: B: 40 Hz sound

Behavioral: C: Preferred music

Behavioral: A: 40 Hz music

2

Experimental group

Description:

this group will be exposed to condition B first, then C, and A

Treatment:

Behavioral: B: 40 Hz sound

Behavioral: C: Preferred music

Behavioral: A: 40 Hz music

3

Experimental group

Description:

this group will be exposed to condition C first, then A, and B

Treatment:

Behavioral: B: 40 Hz sound

Behavioral: C: Preferred music

Behavioral: A: 40 Hz music