Source Monitoring Déficit in Neuropsychiatric Population

Hôpital le Vinatier

Status: Enrolling

Conditions: Psychiatric Disorder

Treatments: Other: Monitoring source test

Study type: Interventional

Funder types: Other

Identifiers

NCT03886584

2018-A00584-51

Details and patient eligibility

About

the investigators will measure source-monitoring ability in patients with several neuropsychiatric condition and in healthy controls appaired in age, sex and educational level. Source-monitoring will be measured thanks to internal- and reality-monitoring informatic tasks.The investigators hypothesized patients with fronto-temporal abnormalities would show more marked deficits than patients with only frontal abnormalities.

Full description

Source-monitoring abilities will be measured thanks to reality-monitoring testing (i.e. the ability to distinguish internal-generated events from external ones) and internal-monitoring testing (i.e. the ability to distinguish an imagined source from a performed one). A source-monitoring deficit have been demonstrated in patients with psychiatric conditions such as schizophrenia and seems linked to frontotemporal abnormalities (frontotemporal dysconnectivity and temporal hypoactivity). With a total of 150 patients, the investigators will include 30 patients per group: patients with pre-dementia stage Alzheimer, Alzheimer, Fronto-Temporal dementia, Lewy Body dementia or Parkinson and Bipolar Disorder, with the hypothesis that Bipolar Disorder patients will present less marked deficit. The investigators will recruit 150 healthy controls.

Enrollment: 300 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Subjects who gave their free and informed consent;
• Men and women;
• Aged 18 to 80;
• Having normal or corrected vision;
• Mastering the French language (read and spoken);
• All subjects will not have a working memory deficit preventing the test from being passed (MMSE short version):AM patients should have a score of <MMSE <26; Patients with pre-dementia AD will be diagnosed according to Dubois criteria (Dubois et al., 2016); patients with early FTD will be diagnosed according to Rascovsky's criteria (Rascovsky et al., 2011); Patients with DCL will be diagnosed according to McKeith's criteria (McKeith et al., 2005), TBP patients will be diagnosed using DSM 5 criteria (Arlington VA, 2013).

Exclusion criteria

• Inadmissibility of the consent or refusal of the subject.
• Patients under guardianship

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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300 participants in 2 patient groups

Patients with with neuropsychiatric conditions

Experimental group

Description:

In this arm, five groups : * Patients with DFT, diagnosed according Racovsky criteria * Patients with Lewi Body dementia, diagnosed according McKeith criteria * Patients with pre-demential Alzheimer, diagnosed according Dubois criteria * Patients with Alzheimer, diagnosed according MMSE * Patients with bipolar disorder, diagnosed according DSM 5

Treatment:

Other: Monitoring source test

Healthy subjects

Active Comparator group

Description:

Healthy controls appaired in age, sex and educational level

Treatment:

Other: Monitoring source test