Southend Imaging Study (SIS)

Mid and South Essex NHS Foundation Trust

Status

Completed

Conditions

Cognition Disorders

Treatments

Other: Neuropsychological tests

Other: fMRI

Study type

Observational

Funder types

Other

Identifiers

NCT02736396

P0867

Details and patient eligibility

About

The study objective is to correlate global cognition and episodic memory performance to resting state fMRI functional connectivity. This is a non-treatment, prospective, natural history data collection study in a cross-sectional cohort of patients with cognitive impairment.

Full description

At present, Magnetic Resonance Imaging (MRI) is widely used along with other tests to help diagnose dementia, however diagnosis still remains challenging. There is currently a focus on the usefulness of resting state functionalMRI (RS fMRI) as a way of establishing differences in functional connectivity between healthy subjects and those with various neurodegenerative disorders. Although the potential for RS fMRI to be used as a biomarker for neurological diseases looks promising, further research is needed, especially regarding validation of normal values and seed-based functional connectivity. Further research into this area will help to improve the ability to appropriately classify new subjects and ultimately allow use of RS functional connectivity as a biomarker. This is a nontreatment, prospective, natural history data collection that aims to analyse functional connectivity in a cohort of patients with suspected cognitive impairment. Correlation of global cognition and episodic memory performance to resting state fMRI functional connectivity will be evaluated. Patient population will include patients over the age of 18 with cognitive impairment and age and gender matched controls. Eligible patients will have to complete neuropsychological and clinical assessments and complete an fMRI scan prior to enrolment.Study duration is estimated at 4 years.

Enrollment

37 patients

Sex

All

Ages

18 to 100 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Informed consent
Cognitive impairment
Age from 18 to 100 years
On stable medication for 1 month before the screening visit; on or off cholinesterase inhibitors
Fluency in English and adequate premorbid intellectual functioning

Exclusion criteria

Any contraindication to MRI scanning
Clinically significant psychiatric disorder (e.g. depression)
Current clinically significant illness that could confound the results of the study
History of alcohol or drug dependence or abuse
Current use of anticonvulsant or narcotic medications.