Spanish Study to Analyze the Histopathological, Ultrastructural and Microbiological Findings Obtained in Autopsies of Patients Who Died Due to COVID-19

Maimónides Biomedical Research Institute of Córdoba

Status: Unknown

Conditions: Covid19

Treatments: Other: Autopsy

Study type: Observational

Funder types: Other

Identifiers

NCT04772833

NECROVID

Details and patient eligibility

About

The aim of this study is prospectively analyzing the histopathological, ultrastructural and microbiological findings from autopsies performed on patients with COVID-19.

Full description

The aim of this study is to increase the knowledge of the pathogenic mechanisms of the COVID-19 disease, that will allow us to improve the design of clinical and therapeutic strategies against the disease. This is the tool to improve the prognosis of patients with COVID-19.

The performance of systematic and regulated autopsies can help to manage it. However, despite the need to generate this knowledge and the strong impact on mortality caused by the COVID-19 pandemic, the evidence from post-mortem studies is very limited.

Enrollment: 50 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with COVID-19 infection confirmed by PCR.
• Death related to active infection by COVID-19 or its complications.
• Informed consent given by the subject's relatives to perform an autopsy according to the autonomous community requirements.
• Informed consent given by the subject's relatives for the inclusion of samples in the Biobank.

Exclusion criteria

• COVID-19 infection diagnosed exclusively by serological methods.
• Advanced or terminal chronic disease.
• Inadequate security level of the autopsy room.

Trial design

50 participants in 1 patient group

Autopsy group

Description:

Patients with COVID-19 infection confirmed by PCR, whose death is related to active COVID-19 infection or its complications.

Treatment:

Other: Autopsy