Spatially Transcriptomics Reveals Molecular Signatures in CRPS

Seoul National University

Status: Enrolling

Conditions: Complex Regional Pain Syndromes

Study type: Observational

Funder types: Other

Identifiers

NCT05986461

2304-052-1421

Details and patient eligibility

About

This observational study aims to understand phenotype-specific molecular signatures in patients with complex regional pain syndrome (CRPS).

Full description

Participants who meet the diagnostic criteria for CRPS, aged 19~80 years, and agree to participate in this study will undergo a 4mm-sized skin punch biopsy in the involved limb, as well as the contralateral side (internal control).

Spatial transcriptomics will be used to identify immune cell signatures and differentially regulated genes (DEGs) in the epidermis, vasculature, sweat gland, and nerve plexus of the involved ipsilateral (vs contralateral) side of the patient's skin.

Enrollment: 10 estimated patients

Sex: All

Ages: 19 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Meets the Budapest diagnostic criteria
• Consents to participation in this study
• Aged between 19 and 80 years old
• Symptoms and/or signs of sensory, vasomotor, and sudomotor changes

Exclusion criteria

• Who do not agree to participate in this study
• Who has contraindications for skin punch biopsy (e.g. thrombocytopenia, taking anticoagulant drugs)