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This study aims to identify spatiotemporal alterations in thalamocortical circuitry functioning in both healthy subjects and patients with chronic pain, combining multimodal neuroimaging.
Full description
Investigators will pursue this goal in both experimental and clinical models at two sites (Florida State U/FSU & Mass General Hospital/MGH), implementing parallel enrollment of large and diverse samples (140 healthy participants and 60 patients with chronic low back pain/cLBP). Leveraging the fully developed multimodal neuroimaging methodology-simultaneous EEG-fMRI and combined EEG-MEG-fMRI, the investigators will investigate TC dysconnectivity (fMRI) and alpha dysrhythmia (EEG/MEG) during experimental pressure pain and chronic back pain.
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Inclusion and exclusion criteria
Healthy subjects for both MGH and FSU sites
Inclusion Criteria:
Exclusion Criteria:
Subjects with chronic low back pain (MGH site)
Inclusion Criteria:
Exclusion Criteria:
200 participants in 2 patient groups
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Central trial contact
Jian Kong
Data sourced from clinicaltrials.gov
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