Specific Bile Microorganisms Caused Intra-abdominal Abscess on Pancreaticoduodenectomy Patients: Customized Antibiotics And Antifungal Medication May Be Necessary

National Taiwan University

Status: Completed

Conditions: Intraabdominal Abscess After Procedure

Treatments: Other: Pancreaticoduodenectomy

Study type: Observational

Funder types: Other

Identifiers

NCT05011630

201803035RIND

Details and patient eligibility

About

Background Intra-abdominal abscess (IAA) is one of the most serious surgical infectious complications on pancreaticoduodenectomy (PD) patients. Preoperative biliary drainage (PBD) is considered as a risk of surgical infectious complications. However, the reason why PBD caused IAA was unknown. In this study, we hypothesize that bile contamination may increase the rate of IAA as bile from residual common bile duct (CBD) leaks and contaminates the abdominal cavity.

Methods We retrospectively collected PD patients with performance of bile culture between 2007 and 2019 in our institute. As to bile culture, we used a swab to do intraoperative bile cultures after transection of the CBD. IAA was defined as a postoperative fluid collection managed by CT-guided placement of drains with documental bacteriological culture.

Enrollment: 539 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• all pancreaticoduodenectomy patients

Exclusion criteria

• no bile cultures

Trial design

539 participants in 2 patient groups

IAA group

Description:

Intraabdominal abscess (IAA) is defined as either a turbid discharge from the intraoperatively placed drain or a postoperative fluid collection managed by CT-guided placement of drains with documental bacteriological culture.

Treatment:

Other: Pancreaticoduodenectomy

Non-IAA group

Description:

No IAA formation

Treatment:

Other: Pancreaticoduodenectomy