Specific Cognitive Remediation for Schizophrenia (RECOS)

Hôpital le Vinatier

Status: Completed

Conditions: Schizophrenia

Treatments: Behavioral: cognitive remediation

Study type: Interventional

Funder types: Other

Identifiers

NCT01607424

RECOS

Details and patient eligibility

About

Rationale:

Cognitive deficits are a core feature in schizophrenia. Conventional treatments (antipsychotic medication and psychological treatments) have limited effects so cognitive remediation programs were designed to alleviate the problems. Interventions typically involve a variety of exercises in a paper and pencil or a computerized format with a growing number of specialized computer programs now being developed. However, many of these programs lack specificity which does not allow an individual's specific needs to be addressed. More targeted interventions might increase the effects of therapy so RECOS - COgnitive REmediation for Schizophrenia - was developed to fit this gap.

Methods: This is a multicenter, randomized, controlled study comparing patients aged 18 to 45 years suffering from schizophrenia according to DSM-IV-TR. RECOS will be compared to an already validated program (CRT).

220 patients will be randomized as follows :

• Arm 1 : RECOS (42 h)
• Arm 2 : CRT (42 h) The recruitment is performed by psychiatrists in Lyon, Paris, Clermont-de-l'Oise, Niort, Bordeaux, Ville-Evrard and Lausanne.

Enrollment: 151 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• men and women aged 18 to 45 years
• French speaker or French schooling since 7 years
• clinical stability
• diagnosis of schizophrenia

Exclusion criteria

• visual or auditory disorder
• history of neurological illness or trauma
• alcohol or drug dependence
• mental retardation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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151 participants in 2 patient groups

RECOS: 42 hours CR, 14 week-treatment.

Experimental group

Description:

RECOS(Cognitive Remediation for Schizophrenia) exercises were designed by SBT Company and adapted by Vianin et al (2007) for specific use in schizophrenia. It includes computer based and paper and pencil exercises that target 5 main cognitive functions. RECOS modules focus on the relevant cognitive domains, which have been recommended by the MATRICS consensus. Each exercise has 10 difficulty levels. Allocation of the training modules in RECOS was determined according to the standard scores obtained in the comprehensive neuropsychological assessment. Each patient participated in the module corresponding to his/her most altered cognitive area.

Treatment:

Behavioral: cognitive remediation

CRT: 42 hours CR, 14 week-treatment

Active Comparator group

Description:

CRT (Cognitive Remediation Therapy) exercises are the ones used by Wykes et al (1999). The CRT method consists of 3 modules: flexibility, memory (A and B) and planning (A and B). Each module involves a series of paper and pencil exercises with parallel forms providing with gradual difficulty.

Treatment:

Behavioral: cognitive remediation