Specific Dietary Fibers May Enhance Colonic Adaptation in Short Bowel Syndrome Through Microbial and Metabolic Mechanisms That Drive Functional Compensation.

Jinling Hospital, China

Status: Completed

Conditions: Short Bowel Syndrome

Treatments: Dietary Supplement: Dietary fiber intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT07186608

20250918

Details and patient eligibility

About

Ten patients with short intestines in clinical practice were intervened with dietary fiber. Serum and feces before and after the dietary fiber intervention were collected, and relevant indicators of nutrition and intestinal barrier were collected to observe the improvement of dietary fiber on patients with short intestines

Enrollment: 10 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

All participants in Cohort 1 were recruited at the Eastern Theatre Command General Hospital (Nanjing, China) and provided written informed consent. The primary inclusion criterion was a confirmed diagnosis of type II or type III short bowel syndrome in patients aged 18

-70 years. Participants were excluded if they had other gastrointestinal diseases, malignant tumours, autoimmune diseases, infectious diseases or renal insufficiency (severe kidney disease with creatinine levels exceeding 3.0 mg/dL), or if they had taken antibiotics for more than three days within the preceding three months.

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Select the party or parties who are masked (blinded) in the clinical study. If there is no masking,

Experimental group

Treatment:

Dietary Supplement: Dietary fiber intervention