Specific Molecular Imaging of DX600 Labeled by PET Radionuclide Targeting ACE2 in Patients

P

Peking University Cancer Hospital & Institute

Status

Completed

Conditions

Solid Tumor

Treatments

Other: 68Ga-DX600 PET/CT

Study type

Interventional

Funder types

Other

Identifiers

NCT04422457
2020KT62

Details and patient eligibility

About

Angiotensin-converting enzyme 2 (ACE2) plays an important role in renin-angiotensin system (RAS) and has been reported to relate with cancer. Recently, it has also been proved as the key target for COVID-19 infection. DX600 is a polypeptide that can specific binding to ACE2 specifically with nanomolar affinity reported in literature. This study constrcuted a radio-tracer, DX600 Labeled by PET Radionuclide, to monitoring biodistribution ACE2 in human beings, evaluate the detection ability of radio-tracer in ACE2 over-expression tumors and dynamic changes of ACE2 expression under therapy.

Enrollment

30 patients

Sex

All

Ages

18 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Age 18-75 years old; both sex;
  • ECoG 0 or 1;
  • Patients that would undergo biopsy or surgical operation with high ACE2 expression tumors such as colorectal cancer, renal cancer, pancreatic cancer, gastric cancer, liver cancer, lung cancer, brain cancer or suspected tumor.
  • use 18F-FDG PET/CT as baseline evaluation

Exclusion criteria

  • Significant hepatic or renal dysfunction;
  • Is Pregnant or ready to pregnant;
  • Cannot lie on their back for half an hour;
  • Suffering from claustrophobia or other mental diseases;
  • Refusal to join the clinical study;

Trial design

Primary purpose

Diagnostic

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

30 participants in 1 patient group

Imaging cohort
Experimental group
Description:
All study participants will be allocated to this arm (single-arm study).Study participants will undergo 68Ga-DX600 PET/CT scans
Treatment:
Other: 68Ga-DX600 PET/CT

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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