Specific Preoperative Dynamic Contrast-enhanced MRI Semi-quantitative Markers Can Correlate With Vascularity in Specific Areas of the Glioblastoma Tissue and Predict Recurrence

Egyptian Medical Syndicate

Status: Completed

Conditions: Glioblastoma

Treatments: Other: Dynamic contrast-enhanced MRI

Study type: Observational

Funder types: Other

Identifiers

NCT04846257

DCE_MRI_GBM

Details and patient eligibility

About

Radiological Markers of vascularity as wash-in rate, washout rate, and capillary time to peak in different single tumour regions were extracted for all glioblastoma patients before being surgically resected from preoperative DCE-MRI. Tissue samples were obtained from different intratumoral regions and peritumoral oedema and evaluated for the vascular endothelial growth factor (VEGF)

Enrollment: 260 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Patients with newly diagnosed glioblastoma with a maximum diameter from 3-5 cm as a single lesion identified by MRI.
• The lesions should be surgically resected at the time of the presentation.

Exclusion Criteria: N/A