Specimen Repository for HIV Immunopathogenesis

AIDS Healthcare Foundation (AHF)

Status: Completed

Conditions: HIV-1-infection; Acute HIV Infection

Study type: Observational

Funder types: Other

Identifiers

NCT03579381

AHF 03

Details and patient eligibility

About

Specimen Repository for HIV Immunopathogenesis Studies

Full description

The goal is to build a large specimen repository for collaborating scientists to run studies of immunity and HIV-1.

Enrollment: 9 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. HIV positive (acutely infected, viremic and elite controllers)
2. Signed Informed Consent Form
3. Age at least 18 years old
4. Immune controllers, two types: "Elite suppressors" (HIV-positive with any three consecutive plasma HIV-1 RNA PCR undetectable while off treatment) or "viremic suppressors" (HIV-positive with any three consecutive HIV-1 RNA PCR <3000 while off treatment).
5. Acutely infected subjects:

Persons identified to have a negative HIV antibody response (ELISA) but positive detection of HIV-1 in the blood (RT-PCR) or individuals who have evidence of a recent (past 30 days) HIV negative result along with a current HIV positive result.

Exclusion criteria

1. Uncontrolled bleeding diathesis.
2. Pregnant.
3. Inability to provide informed consent.

Trial design

9 participants in 2 patient groups

Immune Controllers

Description:

Patients with very low or undetectable levels of viremia without treatment

Acute Infection

Description:

Early infection, i.e. within 2 weeks of infection