SPECT Fibroblast Activation Protein Imaging in Patients With Cardiac Disease

Henan Institute of Cardiovascular Epidemiology

Status: Not yet enrolling

Conditions: Myocardial Fibrosis

Treatments: Diagnostic Test: 99mTc-FAPI SPECT imaging

Study type: Observational

Funder types: Other

Identifiers

NCT06326970

HenanICE202401

Details and patient eligibility

About

This observational study aims to learn about the preliminary exploration of 99mTc-FAPI imaging in heart diseases and its potential application.

Participant involves patients with myocarditis, pulmonary hypertension, arrhythmia, myocardial infarction, dilated cardiomyopathy, and cardiac tumors, health conditions may also studied as control.

The main questions it aims to answer are 1, radionuclide 99mTc labeled fibroblast-activated protein inhibitors (99mTc-FAPI) imaging in the use of cardiac diseases and its limitations. 2, the performance in subjects with different control of hypertension to evaluate myocardial injury and fibrosis for providing a molecular biological basis for the study of diseases and mechanisms.

Participants will undergo 99mTc-FAPI imaging by Single-photon emission computed tomography (SPECT) and record their cardiac disease characterization and treatment.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis or suspected of cardiac injury
• Must be able to receive PET/CT scan

Exclusion criteria

• Pregnant women
• Severe claustrophobia

Trial design

50 participants in 1 patient group

99mTc-FAPI imaging in heart diseases

Description:

Participant involves patients with myocarditis, hypertension, arrhythmia, myocardial infarction, dilated cardiomyopathy, and cardiac tumors.

Treatment:

Diagnostic Test: 99mTc-FAPI SPECT imaging