Spectral Dynamic Imaging of Cognitive Functions in Epileptic Patients Explored Stereoelectroencephalography (ISDETSEEG)

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Epilepsy

Treatments: Device: Hybride electrode; Procedure: Spectral Dynamic Imaging; Device: Macro electrode

Study type: Interventional

Funder types: Other

Identifiers

NCT02869698

38RC09.012

Details and patient eligibility

About

This prospective research aims to develop the use of Spectral Imaging in addition Dynamics of cortical electrical stimulation to identify major anatomical and functional networks in epileptic patients candidates for surgery and explored by stereoencephalography, to minimize risk of post-surgical cognitive deficits.

Full description

Cognitive deficits after epilepsy surgery are poorly known particularly because the tools used to evaluate them. In addition, the prevention of certain postoperative deficits, is extremely difficult because of the lack of robust markers to anticipate. The various examinations conventionally used for this purpose (neuropsychological testing, functional MRI and cortical stimulation) does indeed provide insufficient information or difficult to interpret, so the development of improved methods appears as an imperative in the field of the epilepsy surgery.

SID appears as such particularly adapted to the case of epileptic patients explored SEEG to provide individualized cognitive map millimeter thereof without requiring, for additional invasive act, or risk of inducing unintended crisis. In practice, this clinical research project should lead to the definition of several simple cognitive tasks which, together, could be achieved by each volunteer patient in two or three hours, and then analyzed in a similar time to provide fast, even the patient is still explored SEEG and even before cortical electrical stimulation, a list of brain regions involved in most major cognitive functions.

Enrollment: 192 patients

Sex: All

Ages: 6 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Drug-resistant partial epilepsy justifying a SEEG exploration
• Intellectual capacities compatible with the award of cognitive tasks

Exclusion criteria

• Pregnant or lactating women
• Patient deprived of liberty by a judicial or administrative
• Major patient subject to a measure of legal protection

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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192 participants in 1 patient group

Evaluation of cognitive functions by Spectral Dynamic Imaging

Experimental group

Description:

Evaluation of cognitive functions by SDI will be conducted during the exploration SEEG (which usually lasts from 1 to 3 weeks), and started a few days after implantation of intracranial electrodes

Treatment:

Procedure: Spectral Dynamic Imaging

Device: Macro electrode

Device: Hybride electrode