Spectroscopic Profiling of Extracellular Vesicles By Resonant Gold Nanostructures in the Infrared (PROVEIR_1)

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Enrolling

Conditions: Vesicle

Treatments: Diagnostic Test: sierological test

Study type: Observational

Funder types: Other

Identifiers

NCT06266195

5452

Details and patient eligibility

About

Extracellular vesicles, due to their ease of extraction and ability to represent the cells from which they originate, have high potential in the field of personalized medicine, especially in the identification of new early bio-markers of cancer, including hepatocellular carcinoma. Nevertheless, the development of high-throughput diagnostic methods in this area is still in its infancy, and the design of new integrated technological solutions is of great interest and topicality. The main hypothesis of this study is that the development of a novel technology integrating resonant gold nanostructures in the mid-infrared can significantly contribute to the development of new approaches for the diagnosis of hepatocellular carcinoma.

Enrollment: 64 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion

• 18 years old with a diagnosis of liver cirrhosis of different etiology
• 18 years old with a diagnosis of hepatocellular carcinoma

Exclusion

• Have not signed the informed consent
• Pregnant women

Trial design

64 participants in 2 patient groups

GRUPPO CIRROSI

Description:

32 soggetti uomini o donne, \>18 anni con diagnosi di cirrosi epatica di differente eziologiA

Treatment:

Diagnostic Test: sierological test

GRUPPO HCC

Description:

32 pazienti uomini o donne, con diagnosi di neoplasia primitiva del fegato

Treatment:

Diagnostic Test: sierological test