Spectroscopy in Ovarian Cancer

University of Exeter

Status: Completed

Conditions: Ovarian Neoplasms; Ovary Cyst; Ovary Disease; Ovarian Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT04817449

2020-21-12

Details and patient eligibility

About

Ovarian cancer is the eighth most common cause of cancer death in the world. Advanced stage at diagnosis is associated with lower survival rates, thus early detection appears to have an important role.

Raman Spectroscopy is a non-invasive technique that uses the interaction of light to identify the composition of the sample tested.

The aim of the project is to explore the use of spectroscopic techniques in the detection of ovarian cancer. There are two different assessments within the project:

1. Identify ovarian cancer in blood - Raman spectroscopic analysis will be performed on blood plasma taken from patients with suspected ovarian cancer.
2. Detect active cancer within post chemotherapy fibrotic tissue - Ex vivo Raman spectroscopic analysis of peritoneal, omental or ovarian tissues collected from patients undergoing surgical treatment for ovarian cancer.

The results of the spectroscopy will be correlated to clinical outcome and histological diagnosis respectively.

Enrollment: 160 patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Female
• Symptoms suggestive of ovarian cancer
• Patients undergoing treatment of Ovarian Cancer

Exclusion criteria

• Less than 18 years of age
• Unable to consent to the study due to communication difficulties
• Unable to consent to the study due to lack of capacity

Trial design

160 participants in 1 patient group

Suspected Ovarian Cancer

Description:

Patients referred or self presenting to secondary care with signs or symptoms of ovarian cancer.