Spectroscopy in Parkinson Disease (SPIN-PD)

Molecular Biometrics

Status: Unknown

Conditions: Parkinson Disease

Treatments: Other: Blood draw

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT01005030

MB_PD001

Details and patient eligibility

About

The primary objective of the study is to determine the utility of blood plasma infrared spectroscopy (biospectroscopy) in distinguishing subjects with idiopathic Parkinson's disease from healthy controls.

Full description

Oxidative stress has been implicated as a factor in the pathogenesis of Parkinson's disease (PD). The overall goal of this proposal is to use a novel metabolomics platform, based on near infrared biospectroscopy, to detect oxidatively modified blood plasma constituents. These spectral findings can be used to model the degree of oxidative stress with a modeled "stress index" that may distinguish PD cases from healthy elderly controls.

Enrollment: 500 estimated patients

Sex: All

Ages: 46+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

PD Subjects:

1. PostCEPT subjects with a diagnosis of PD based on UK Brain Bank criteria.
2. Willing and able to provide informed consent.

Healthy Controls:

1. No current diagnosis or known history of a neurological disease/disorder.
2. Non-blood relative of a patient or subject at the site who has diagnosis of PD (may include healthy controls from the PROBE study).
3. No first degree relatives with diagnosis of PD
4. MoCA score > 26.
5. Age > 45.
6. Willing and able to provide informed consent.

Trial design

500 participants in 2 patient groups

PostCEPT Subjects

Description:

Subjects with current Parkinson Disease Diagnosis currently enrolled in PostCEPT study

Treatment:

Other: Blood draw

Control Subjects

Description:

Non-blood relatives of PostCEPT Subjects matched for age and other demographics

Treatment:

Other: Blood draw