Speech Signals in Stuttering

University of Pittsburgh

Status

Enrolling

Conditions

Stuttering, Childhood

Treatments

Behavioral: Speech sound stimulation

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT05668923

1R01DC019904-01 (U.S. NIH Grant/Contract)

STUDY21120103

Details and patient eligibility

About

The purpose of this research study is to understand how speech and language are processed in the brain. This study will provide information that may help with the understanding how speech and language are processed in children and whether there may be differences between children who stutter and children who do not stutter. This project will evaluate these neural processes for speech signals in children who stutter and control subjects through a battery of behavioral speech and language tests, electroencephalography-based (EEG) tasks, functional magnetic resonance imaging (fMRI), and computational modeling.

Full description

The study will evaluate the integrity of neural processes underlying speech sound encoding and the ways in which these processes are modulated by task demands using neuroimaging and computational modeling.

Age-appropriate standardized tests for assessing speech, language, and cognitive skills will be administered by a certified speech language pathologist or trained lab member.

The investigators will also measure electroencephalography (EEG) via frequency following responses (FFRs) and temporal response functions (TRFs) while children complete speech-sound tasks of varying difficulty including syllable listening and identification and continuous speech narrative comprehension tasks. Both tasks will be presented in both quiet and in background noise. EEG signals will be collected using Ag-AgCl scalp electrodes, and responses will be recorded at a sampling rate of 25 kHz using Brain Vision Recorder (Brain Products, Gilching, Germany).

The investigators will also leverage functional MRI (fMRI) to assess multiple neural systems underlying speech sound processing in children who stutter in a 3T scanner. Employing similar speech-sound tasks in the same participants as the EEG tasks will allow for quantifying neural activations and representations in auditory, speech motor articulatory, and attention networks during simple and complex speech tasks. A series of MRI scans will be recorded to provide data regarding the participant's brain anatomy. These scans will be analyzed on their own and also used in combination with functional scans. All participants will be screened for metal and other objects that are not appropriate for the MRI scanner room. Participants will be given earplugs and/or headphones to wear.

Enrollment

600 estimated patients

Sex

All

Ages

5 to 17 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Speaks English as primary language
Language abilities within the typical range
Cognitive abilities within the typical range
No contraindications for MRI

Inclusion criteria for children who stutter:

Presence of developmental stuttering (onset in childhood)
No history of other communication disorder

Inclusion criteria for children who do not stutter:

No family history of stuttering
No history of other communication disorders (e.g., hearing impairment, language impairment, cognitive impairment/injury)

Exclusion criteria

Taking medication that alters neural function
Cognitive skills below the typical range
Major medical illness
Not a fluent speaker of English
Pregnant or possibly pregnant
Metal implants in your body (including pacemakers, neurostimulators, or other metal objects)
Shrapnel injuries
Ocular foreign bodies (e.g., metal shavings)
Metal piercings that cannot be removed for the scan
Tattoos containing iron or metal pigments
Prone to claustrophobia
For fMRI, those with head circumference greater than 60cm or whose weight is more than 300 pounds will be excluded due to the size of the fMRI magnet bore