Speech Therapy and Repetitive Transcranial Magnetic Stimulation Therapy in Post-stroke Anomic Aphasia

Ege University

Status: Completed

Conditions: Aphasia, Anomic; Stroke; Aphasia

Treatments: Device: Repetitive transcranial magnetic stimulation; Other: Speech therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT04625790

Anomia-rTMS

Details and patient eligibility

About

The aim of the study is to observe the effects of speech therapy and transcranial magnetic stimulation therapy in patients who develop anomic aphasia after stroke. Patients meeting the inclusion criteria will be randomly divided into groups. In the repetitive transcranial magnetic stimulation (rTMS) treatment group, a total of 10 sessions, 1 session per day, will be applied to the right inferior frontal gyrus area with a frequency of 1 Hz for 20 minutes. The control group patients will be given speech therapy in the same way, but no active magnetic stimulation will be given in rTMS sessions (sham application). Speech therapy will be given to each patient by the same physiotherapist, and the treatment will last a total of 10 days, 60 minutes a day. Minimental test (MMT), Ege aphasia test, aphasia quality of life scale (SAQOL-39) will be filled in to the patients before and after the treatment.

Enrollment: 25 patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Stroke diagnosed with cranial MR examination causing unilateral hemiplegia
• Post-stroke patients with anomic aphasia
• 40-70 years
• Being able to read the basic instructions
• Medically and neurologically stable patients

Exclusion criteria

• Clinical condition that will constitute a contraindication to TMS (metallic implant, Cardiac pacemaker, pregnancy, breastfeeding, epilepsy, head trauma...)
• Having previously had TMS treatment
• Presence of Life-threatening disease and/or active systemic disease (chronic disease, malignancy ...)
• Alcohol or drug addiction
• Presence of neurodegenerative or psychiatric disorders
• Pregnancy or breastfeeding status
• Severe cognitive impairment
• Having a history of previous epilepsy
• Visual and auditory impairment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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25 participants in 2 patient groups, including a placebo group

Study group

Experimental group

Description:

After randomization, this group will take 10 sessions of 1-Hz low frequency rTMS will be applied to the inferior frontal gyrus of the right frontal lobe for 20 minutes during the stroke treatment process before 10 days of speech therapy. Speech therapy will be given to each patient by the same therapist who is qualified in this field, and the treatment will last 10 days, 60 minutes a day.

Treatment:

Other: Speech therapy

Device: Repetitive transcranial magnetic stimulation

Control group

Placebo Comparator group

Description:

This group will take 10 sessions of sham rTMS for 20 minutes during the stroke treatment process before 10 days of speech therapy. The sham therapy will consist of positioning the coil on the cranium at the same spot, but without a magnetic stimulation, only with the device open and the sounds will be audible. Speech therapy will be given to each patient by the same therapist who is qualified in this field, and the treatment will last 10 days, 60 minutes a day.

Treatment:

Other: Speech therapy