Speeded Anomia Treatment in Chronic Post-stroke Aphasia

University of Cambridge

Status: Enrolling

Conditions: Aphasia

Treatments: Behavioral: Speeded anomia therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT05512884

01/8/094

Details and patient eligibility

About

The main aim of the study is to investigate the effect of a novel, speeded anomia therapy (Conroy et al., 2018) in a large population of patients with chronic post-stroke aphasia. The treatment will be delivered via a web application (QuickWord).

Full description

The main aim is to test the clinical efficacy of a novel, web based, rehabilitation approach to aphasic word-finding difficulties (QuickWord). In an initial development and case-series evaluation, Conroy et al (2018, Brain) found that training for both speed as well as accuracy of naming generated much better outcomes to picture naming accuracy and also augmented the carry-over to connected speech production.

This is a randomised, crossover, clinical trial of QuickWord in a group of aphasic patients in the chronic post-stroke period. The comparison will be standard care. The main outcome measures are clinically relevant improvement in naming to confrontation, and spontaneous use of the target vocabulary in a connected speech sample (detailed picture description). Secondary outcome includes measured use of the vocabulary in a story-telling, connected speech assessment (retelling of the Cinderella story).

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Native English speakers
• Age 18 years or above
• Stroke (any type) greater than 12 months post onset
• No history of neurological disorders / psychiatric disorders
• Normal or corrected-to-normal hearing & vision
• Able to give informed consent
• Currently not receiving Speech & Language therapy
• Minimal repetition skills (>40% on an immediate word repetition test)
• Evidence of naming difficulties (<90% in Boston Naming Test - Goodglass et al., 1983)

Exclusion criteria

• Non-native English speakers
• Less than 18 years old
• Stroke less than 12 months post onset
• History of neurological disorders / psychiatric disorders
• Uncorrected hearing & vision
• Unable to give informed consent
• Currently receiving Speech & Language therapy
• Insufficient repetition skills (<40% on an immediate word repetition test)
• Good naming performance (>90% in Boston Naming Test - Goodglass et al., 1983)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Speeded anomia therapy

Experimental group

Description:

21h of anomia therapy

Treatment:

Behavioral: Speeded anomia therapy

Standard care

No Intervention group

Description:

Participants' typical daily routine