Sperm Capacitation Assay as a Tool to Predict Sperm Potential to Fertilize in IVF Treatment

Shamir Medical Center (Assaf-Harofeh)

Status: Unknown

Conditions: Sperm Capacitation

Treatments: Other: biologic; Other: sperm capacitation

Study type: Observational

Funder types: Other

Identifiers

NCT00731159

54/08

Details and patient eligibility

About

Our aim is to evaluate the potential of a new laboratory method that measure sperm capacitation to predict fertilization of oocytes in patients that undergo IVF treatments

Full description

Capacitation is a physiologic process in which the sperm acquire the potential to fertilize oocytes. Capacitation can be measured, but the available technics are expensive, inaccurate and complex. A new method to evaluate sperm capacitation was developed in Bar Ilan University, Israel. We intend to measure the capacitation of semen that is used for fertilizing human oocytes in patients treated at the IVF unit at Assaf Harofeh Medical Center.By this, to evaluate the potential of the new method to predict human oocyte fertilization.If the method will be found valuable, it will enable to develop new drugs/methods that may improve sperm capacitation and by this to improve oocyte fertilization leading to more embryos, pregnancies and deliveries.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients requiring IVF within the "routine" work of an IVF Unit
• normo-responding woman
• non ICSI cycles

Exclusion criteria

• Patients undergoing ICSI only cycle
• Low responders-less than 8 oocytes
• Male patients with low semen volume

Trial design

50 participants in 1 patient group

A

Description:

Sperm capacitation: Sperm capacitation is measured in a sample of the same ejaculated sperm unit given for fertilizing human oocytes in an IVF treatment cycle

Treatment:

Other: sperm capacitation

Other: sperm capacitation

Other: biologic