Sperm DNA Damage in β-thalassemia Major: Is There a Role for Antioxidants?

Ain Shams University

Status and phase: Unknown; Phase 2; Phase 1

Conditions: Endocrine Disease; Fertility Decreased Male; DNA Damage

Treatments: Drug: L-Carnitine and N-acetyl cysteine

Study type: Interventional

Funder types: Other

Identifiers

NCT03014882

Endocrinology PECASU

Details and patient eligibility

About

Accumulation of iron in patients with beta thalassemia major causes free radical formation which leads to damage of biological membranes. Sperm DNA damage may result from these generated antioxidants.

We aimed at investigating the current DNA damage in the sperms of adult patients with beta thalassemia major and the effect generated by giving antioxidant treatment for 6 months.

Enrollment: 30 estimated patients

Sex: Male

Ages: 16+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Pubertal patients with beta thalassemia major

Exclusion criteria

• Associated endcrinopathy

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

30 participants in 1 patient group

Antioxidant treatment

Other group

Treatment:

Drug: L-Carnitine and N-acetyl cysteine