Sperm DNA Damage in β-thalassemia Major: Is There a Role for Antioxidants?

A

Ain Shams University

Status and phase

Unknown
Phase 2
Phase 1

Conditions

Endocrine Disease
Fertility Decreased Male
DNA Damage

Treatments

Drug: L-Carnitine and N-acetyl cysteine

Study type

Interventional

Funder types

Other

Identifiers

NCT03014882
Endocrinology PECASU

Details and patient eligibility

About

Accumulation of iron in patients with beta thalassemia major causes free radical formation which leads to damage of biological membranes. Sperm DNA damage may result from these generated antioxidants. We aimed at investigating the current DNA damage in the sperms of adult patients with beta thalassemia major and the effect generated by giving antioxidant treatment for 6 months.

Enrollment

30 estimated patients

Sex

Male

Ages

16+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Pubertal patients with beta thalassemia major

Exclusion criteria

Associated endcrinopathy

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

30 participants in 1 patient group

Antioxidant treatment
Other group
Treatment:
Drug: L-Carnitine and N-acetyl cysteine

Trial contacts and locations

3

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Data sourced from clinicaltrials.gov

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