Sperm DNA Damage to Intracytoplasmic Sperm Injection Outcome

Assiut University

Status: Completed

Conditions: Infertility, Male

Treatments: Diagnostic Test: Sperm DNA integrity by flow cytometry

Study type: Observational

Funder types: Other

Identifiers

NCT03129243

ICSI

Details and patient eligibility

About

In the current era of assisted reproductive techniques where technology can help overcome defects in sperm function, the value of semen analysis has become even more inaccurate. Initial reports of intracytoplasmic sperm injection revealed its ability to bypass the natural selection process and enable men with severely impaired semen parameters to achieve both clinical pregnancy and live birth

Enrollment: 120 patients

Sex: Male

Ages: 20 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Infertile male patients with abnormal semen parameters.
2. Normal female partner aged <38 years.

Exclusion criteria

1. Female patients with obvious infertility factor.
2. Male patients with azoospermia.
3. Male patients with systemic diseases.
4. Male patients receiving cytotoxic therapy.
5. Male patients with genital pathology as cryptorchidism.