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Sperm DNA Fragmentation Effects on Blastocyst Morphology Grading, Pregnancy Rate and Implantation Rate

G

Ganin Fertility Center

Status

Completed

Conditions

Blastocyst
Implantation Rate

Treatments

Procedure: ICSI

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

Retrospective cohort study for 189 couples assigned to normal and abnormal Sperm DNA fragmentation (SDF) groups.To determine the effect of SDF on blastocyst's trophectoderm (TE), Inner cell mass (ICM) morphology grading, and implantation rate. Semen in both groups was processed by density gradient (DG).

Full description

Purpose: to determine if sperm DNA fragmentation (SDF) has a correlation with Blastocyst's trophectoderm (TE) and Inner cell mass (ICM) grading, or with the implantation rate?

Method: Retrospective cohort study for 189 couples, assigned to normal SDF group (121 cases), and abnormal SDF group (68 cases). Semen in both groups was processed by double layer density gradient (DG).

Statistical analysis done using SPSS version 22.

Enrollment

189 patients

Sex

All

Ages

Under 37 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • All cases in this study have to reach the blastocyst stage.
  • Female age ≤37 years old.
  • Male sperm count ≥ 5 million.

Exclusion criteria

  • Usage of sperm selection techniques.
  • Testicular aspiration or testicular biopsies.
  • Oocyte or sperm donation.

Trial design

189 participants in 2 patient groups

Normal SDF
Description:
Couples with male partners having SDF lower than 20% using TUNEL assay
Treatment:
Procedure: ICSI
Abnormal SDF
Description:
Couples with male partners having SDF greater than 20% using TUNEL assay
Treatment:
Procedure: ICSI

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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