Spermidine Intake and All-cause Mortality

Medical University Innsbruck

Status: Completed

Conditions: Mortality; Healthy Diet

Treatments: Other: Spermidine content of natural diet

Study type: Observational

Funder types: Other

Identifiers

NCT03378843

Bruneck_2017_Spermidine

Details and patient eligibility

About

This study seeks to test the potential association between spermidine content in diet and mortality in humans.

Full description

This prospective community-based cohort study includes 829 participants aged 45-84 years, 49.9% of which are male. Diet is assessed by repeated dietician-administered validated food-frequency questionnaires (2540 assessments) in 1995, 2000, 2005, and 2010. Nutrient intakes including spermidine are calculated using USDA standard databases. Clinical events (all-cause mortality and cause-specific mortality) are recorded from 1995 to 2015.

The primary endpoint of all-cause mortality is related to the exposure of long-term average spermidine intake by Cox proportional hazards models with time-varying covariates. Additional analyses employ the Fine and Gray proportional subdistribution hazards model and flexible Royston-Parmar spline-based models. Comprehensive sensitivity analyses are performed to guard against potential biases associated with nutritional epidemiology.

Enrollment: 829 patients

Sex: All

Ages: 45 to 84 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Resident of Bruneck aged 40-79 years in 1990, age- and sex-stratified random sample.

Exclusion Criteria: None.