Sphingolipidomic Profile in Anorexia Nervosa (SFINGOANNER)

Istituto Auxologico Italiano

Status: Enrolling

Conditions: Anorexia Nervosa

Treatments: Other: Determination of sphingolipidomic profile

Study type: Observational

Funder types: Other

Identifiers

NCT06800937

01C417

Details and patient eligibility

About

: The objective of this research project will be to determine the sphingolipidomic profile in a group of women (> 18 years) affected by Anorexia Nervosa (AN), phenotypically characterized (restricting [AN-R] vs binge-eating purging [AN-BP]). Specific questionnaires will be administered for the definition of the severity of the eating disorder and depressive state (suicidality), to which will be added the evaluation of gonadal function (i.e., plasma levels of estradiol/progesterone and use of oral contraceptives).

Based on the specific lipidomic profile, which the present research project hopes to characterize, it will be possible to appropriately modify the diet of rehabilitation programs and, in the future, improve the effectiveness of the treatment itself, especially in the long term.

Enrollment: 60 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Patients with Anorexia Nervosa:

Inclusion Criteria:

• Female sex
• Age: 18 years or older
• Diagnosis of Anorexia Nervosa in the acute phase
• Hospitalized at the Division of Eating and Nutrition Disorders (END), San Giuseppe Hospital, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy

Exclusion Criteria:

• Absence of signed Informed Consent

Control group:

Inclusion Criteria:

• Female sex
• Age: 18 years or older
• BMI between 18.5 and 24.9 kg/m2

Exclusion Criteria:

• Absence of signed Informed Consent

Trial design

60 participants in 2 patient groups

Anorexia Nervosa

Description:

Adult female Anorexia Nervosa patients, hospitalized at the Division of Eating and Nutrition Disorders (END), Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy

Treatment:

Other: Determination of sphingolipidomic profile

Normal weight

Description:

Adult normal-weight women with a Body Mass Index between 18.5 and 24.9 kg/m2, recruited from research and hospital staff

Treatment:

Other: Determination of sphingolipidomic profile