Spinal Anaesthesia With Levobupivacaine 0.5% and Ropivacaine 0.75% for Lower Limb Orthopaedic Surgery

Aligarh Muslim University

Status and phase: Completed; Phase 4

Conditions: Lower Limb Surgery

Treatments: Drug: Levobupivacaine; Drug: Ropivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT02201784

jnmch2012

Details and patient eligibility

About

The purpose of this study is to compare the effects of two intrathecally administered drugs:0.5% levobupivacaine and0.75%Ropivacaine in spinal anesthesia

Full description

Bupivacaine is a highly cardiotoxic drug and also produces prolonged motor blockade.The newer drugs levobupivacaine and ropivacaine being comparatively less cardio and neurotoxic are preferred now a days.So, we conducted this prospective, randomized double blind study with an aim of comparing the efficacy and characteristics of these drugs.

Enrollment: 60 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. American Society of Anesthesiologists (ASA) class I & II patients of either sex
2. Age between 18-60 years

Exclusion criteria

1. Patient's refusal.
2. Patients who have contraindications to spinal anaesthesia / Local anaesthetic drugs.
3. Patients having h/o diabetes, neurological and musculoskeletal diseases.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Levobupivacaine 0.5%

Active Comparator group

Description:

intrathecal administration of 15 mg of Levobupivacaine 0.5%

Treatment:

Drug: Levobupivacaine

Ropivacaine 0.75%

Active Comparator group

Description:

intrathecal administration of 22.5 mg of Ropivacaine 0.75%

Treatment:

Drug: Ropivacaine