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Spinal Anaesthesia With Levobupivacaine 0.5% and Ropivacaine 0.75% for Lower Limb Orthopaedic Surgery

A

Aligarh Muslim University

Status and phase

Completed
Phase 4

Conditions

Lower Limb Surgery

Treatments

Drug: Levobupivacaine
Drug: Ropivacaine

Study type

Interventional

Funder types

Other

Identifiers

NCT02201784
jnmch2012

Details and patient eligibility

About

The purpose of this study is to compare the effects of two intrathecally administered drugs:0.5% levobupivacaine and0.75%Ropivacaine in spinal anesthesia

Full description

Bupivacaine is a highly cardiotoxic drug and also produces prolonged motor blockade.The newer drugs levobupivacaine and ropivacaine being comparatively less cardio and neurotoxic are preferred now a days.So, we conducted this prospective, randomized double blind study with an aim of comparing the efficacy and characteristics of these drugs.

Enrollment

60 patients

Sex

All

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. American Society of Anesthesiologists (ASA) class I & II patients of either sex
  2. Age between 18-60 years

Exclusion criteria

  1. Patient's refusal.
  2. Patients who have contraindications to spinal anaesthesia / Local anaesthetic drugs.
  3. Patients having h/o diabetes, neurological and musculoskeletal diseases.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

60 participants in 2 patient groups

Levobupivacaine 0.5%
Active Comparator group
Description:
intrathecal administration of 15 mg of Levobupivacaine 0.5%
Treatment:
Drug: Levobupivacaine
Ropivacaine 0.75%
Active Comparator group
Description:
intrathecal administration of 22.5 mg of Ropivacaine 0.75%
Treatment:
Drug: Ropivacaine

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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