Spinal Cord Analysis in Multiple Sclerosis

University Hospital Basel

Status

Completed

Conditions

Multiple Sclerosis

Treatments

Diagnostic Test: spinal cord MRI

Study type

Observational

Funder types

Other

Identifiers

NCT03841903

2016-01461 me16Kappos2;

Details and patient eligibility

About

Research project in which patients with Multiple Sclerosis (MS) are examined clinically and with magnetic resonance imaging (MRI). To evaluate spinal cord (SC) grey and white matter changes (incl. lesions) using fast, high-resolution MRI sequences with high contrast between SC and cerebrospinal fluid (CSF) as well as high contrast within the SC (grey-white matter contrast).

Full description

The Swiss Multiple Sclerosis Cohort (SMSC-Study) aims to better evaluate specific Multiple Sclerosis (MS) phenotypes through the systematic and standardised documentation and acquisition of clinical course and paraclinical tests such as magnetic resonance imaging (MRI), blood and cerebrospinal fluid (CSF) specimens.

Determination of the relative contribution of SC metrics (cervical cord volume, cervical grey matter (GM) cord volume, cervical white matter (WM) cord volume, SC lesion load) to disability in MS.

Enrollment

79 patients

Sex

All

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria

Diagnosis of multiple sclerosis
Steroid free period: > 4 weeks
healthy controls without any history of severe neurological, internistic or psychiatric disease

Exclusion Criteria for all participants:

History of severe (other) neurological, internistic or psychiatric disease
MRI related exclusion criteria:
1. Paramagnetic and/or superparamagnetic foreign objects in the body
2. Pacemaker
3. Claustrophobia
4. Pregnancy, lactation