Spinal Morphine Provides an Effective Pain Control in Patients Undergoing Transurethral Resection of Prostate Gland

Mahidol University

Status

Completed

Conditions

Spinal Anesthesia

Transurethral Resection of Prostate

Analgesia

Treatments

Drug: Morphine

Drug: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT02458742

019/2558(EC2)

Details and patient eligibility

About

Pain after transurethral resection of prostate is considered mild to moderate severity from detrusor muscle spasm and traction from urinary catheter. Numerous pain relieve methods have been studied including spinal opioids, spinal anesthesia with local anesthetic and dexmedetomidine, periprostatic nerve blockade with bupivacaine and mixing of prilocaine with distilled water irrigation while undergoing a procedure. Most of patients having this procedure are in elderly period, thus many anesthetists avoided spinal morphine which may cause respiratory depressant effect postoperatively. Although previous studies showed effectiveness of spinal morphine 25-200 mcg, some patients suffered from neuraxial opioid side effects.

The aim of this study is to demonstrate efficacy of local anesthetic with intrathecal morphine 50 mcg providing pain relieve after transurethral resection of prostate compare to spinal anesthesia with sole local anesthetic.

Enrollment

80 patients

Sex

Male

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age > or = 18 years old
Undergoing transurethral resection of prostate gland

Exclusion criteria

Contraindication for spinal anesthesia for any reasons eg. infection, bleeding disorder
Refuse spinal anesthesia
Allergic to study drugs
History of cerebrovascular disease or stroke