Spironolactone and Insulin Resistance in Chronic Heart Failure (CHF)

Tottori University Hospital

Status and phase: Completed; Phase 4

Conditions: Chronic Stable Heart Failure

Treatments: Drug: spironolactone + furosemide

Study type: Interventional

Funder types: Other

Identifiers

NCT00664222

#344.1

Details and patient eligibility

About

The purpose of this study is to evaluate the effects of spironolactone and furosemide on insulin resistance in patients with chronic heart failure.

Full description

Diuretics is useful in CHF patients. On the other hand, they deteriorate glucose metabolism. Therefore, the purpose of this study is to evaluate the effects of spironolactone and furosemide on insulin resistance in patients with chronic heart failure.

Enrollment: 16 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• chronic stable heart failure

Exclusion criteria

• renal dysfunction or under treatment with antidiabetic agents

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind