Splenda: Effects on Blood Glucose Concentration, Appetite Scores and Subsequent Energy Intake

King's College London

Status: Completed

Conditions: Appetitive Behavior; Glucose Metabolism Disorders

Treatments: Dietary Supplement: High carbohydrate breakfast; Dietary Supplement: Maltodextrin drink; Dietary Supplement: Splenda drink

Study type: Interventional

Funder types: Other

Identifiers

NCT05810337

KCLMScNutr2023

Details and patient eligibility

About

This study investigates the effects of Splenda, an artificial sweetener powder containing sucralose, on post-prandial blood glucose levels, appetite scores and subsequent energy intake.

Full description

Participants are randomly assigned to receive either the placebo drink (4.5g maltodextrin dissolved in 250ml water) or the Splenda drink (4.5g Splenda dissolved in 250ml water) taken alongside a high calorie breakfast.

Blood glucose measurements will be obtained through finger-pricking and appetite will be measured using self-reported visual analogue scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after breakfast. Energy intake will be measured using a 24 hour food diary.

Enrollment: 51 patients

Sex: All

Ages: 18 to 64 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy male and female adults (18-64 years)

Exclusion criteria

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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51 participants in 2 patient groups, including a placebo group

Splenda drink

Experimental group

Description:

Drink containing 4.5g Splenda dissolved on 250ml water.

Treatment:

Dietary Supplement: High carbohydrate breakfast

Dietary Supplement: Splenda drink

Maltodextrin drink

Placebo Comparator group

Description:

Drink containing 4.5g maltodextrin dissolved on 250ml water.

Treatment:

Dietary Supplement: High carbohydrate breakfast

Dietary Supplement: Maltodextrin drink