Splenic Artery Ligation and Portocaval Shunt in Small-for-size Syndrome (splen ligation)

Aretaieion University Hospital

Status: Completed

Conditions: Splenic Artery; Small-For-Size Liver Syndrome; Ligation; Hepatectomy; Ischemia; Liver Regeneration; Reperfusion Injury; Portal Vein

Treatments: Procedure: splenic artery ligation

Study type: Observational

Funder types: Other

Identifiers

NCT05459883

418/18-04-2022

Details and patient eligibility

About

Our study aimed at assessing the changes of portal vein pressure, portal vein flow and hepatic arterial flow (HAF) in liver remnants ≤ 30% of the standard liver volume by reducing portal vein overflow via ligation of the splenic artery.

Full description

It has been reported that prevention of acute portal overpressure in small-for-size liver grafts leads to better postoperative outcomes. Accordingly, we aimed to investigate the feasibility of the technique of splenic artery ligation in a case series of patients subjected to major liver resections with evidence of small-for-size syndrome and whether the maneuver results in reduction of portal venous pressure and flow.

Enrollment: 13 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients
• American Society of Anesthesiologists (ASA) distribution I to III
• Patients scheduled for major liver resection (≥4 segments)

Exclusion criteria

• patients with extrahepatic disease
• patients with metastatic liver tumors