Split-Face Study Comparing Botox and Jeuveau in Treating Glabellar Lines

University of Southern California

Status and phase: Active, not recruiting; Early Phase 1

Conditions: Glabellar Frown Lines

Treatments: Drug: PrabotulinumtoxinA; Drug: Onabotulinum toxin A

Study type: Interventional

Funder types: Other

Identifiers

NCT04715048

HS-19-00455

Details and patient eligibility

About

The purpose of this study is to compare the efficacy and side effects of Botox and Jeuveau for glabellar lines.

Full description

After being informed about the study and potential risks, all patients given consent will receive Botox on one side of their face and Jueveau on the other. A random number generator will generate a list of 20 combinations of "1,2" or "2,1". "1,2" means the Botox (onabotulinumtoxin A) will be placed on the right side and "2,1" means that the Botox will be placed on the left. The other side will be injected with PrabotulinumtoxinA. 8-10 units will be injected into the designated glabella in 3 sites.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age > 18
• Willingness to participate in the study and able to provide informed consent

Exclusion criteria

• Inability to follow up for study duration
• Prior neurotoxin injection in the last 4 months
• Prior surgery to the glabellar area
• Any planned aesthetic procedure to the glabellar area during the study period
• Cardiac Patients

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Triple Blind

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20 participants in 2 patient groups

Onabotulinumtoxin A

Experimental group

Description:

8-10 units of Botox will be injected in the glabellar lines in one side of the face in 3 different locations. This injection will happen once.

Treatment:

Drug: Onabotulinum toxin A

Prabotulinumtoxin A

Experimental group

Description:

8-10 units of Jeuveau will be injected in the glabellar lines in the other side of the face in 3 different locations. This injection will happen once.

Treatment:

Drug: PrabotulinumtoxinA