Split Renal Function Using 99mTc-DTPA Versus 99mTc-DMSA in Kidney Patients of Wide Age Ranges.

Assiut University

Status: Unknown

Conditions: The Difference in Estimation of Split Renal Function Using the Two Radiopharmaceuticals:Tc-99m DTPA & Tc-99m DMSA in Kidney Patients

Treatments: Other: renal scintigraphy

Study type: Interventional

Funder types: Other

Identifiers

NCT03879005

SRF using DTPA Vs DMSA

Details and patient eligibility

About

To evaluate split renal function using Tc-99m DTPA versus Tc-99m DMSA.

Full description

Split renal function (SPR) is a determination of the relative contribution of each of the two kidneys . It gives a useful information in several conditions such as evaluating unilateral renal disorders, assessing individual kidney function before and after intervention, and before live donor nephrectomy. Different radiopharmaceuticals such as technetium-99m dimercaptosuccinic acid (99mTc-DMSA), technetium-99m diethylenetriaminepentaaceticacid (99mTc-DTPA), technetium-99m mercaptoacetyltriglycine (99mTc-MAG3), Iodine 131 orthoiodohippurate and more recently technetium-99 m ethylenedicysteine (99mTc-EC) were used, However, 99mTc-DMSA as a static renal agent is considered the most reliable method to measure relative renal function and the most appropriate tracer for renal cortical imaging . In some papers, it is emphasized that relative renal function calculated with 99mTc-DTPA is as reliable as 99mTc-DMSA .‬ The investigators design the study to evaluate the difference in estimation of split renal function using the available two radiopharmaceuticals: Tc-99m DTPA and Tc-99m DMSA.

Enrollment: 25 estimated patients

Sex: All

Ages: 2 months to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Kidney patients of wide age ranges.
2. Patients with renal disorders who referred for DMSA and DTPA split renal function.
3. Patients able to sleep in a fixed position for 20 minutes.

Exclusion criteria

1. Children unable to sit calm without movement during imaging.
2. Severely ill patients.
3. Patients with allergy to one or more of material method.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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25 participants in 1 patient group

Renal scintigraphy

Other group

Description:

5 mci of 99mTc-DTPA or 99mTc-DMSA is injected once IV. Dose is adjusted according to age and weight.

Treatment:

Other: renal scintigraphy