Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity

Mayo Clinic

Status: Completed

Conditions: Polymyalgia Rheumatica; Celiac Disease; Vitiligo; Antiphospholipid Antibody Syndrome; Graves Disease; Systemic Lupus Erythematosus; Type 1 Diabetes Mellitus; Multiple Sclerosis; Raynaud; Sjögren Syndrome; Addison Disease; Primary Biliary Cirrhosis; Crohn Disease; Ankylosing Spondylitis; Psoriasis; Dermatomyositis; Guillain-Barre Syndrome; SCAD; Systemic Sclerosis; Takayasu Arteritis; Hepatitis, Autoimmune; Myasthenia Gravis; Uveitis; Polymyositis; Vasculitis; Ulcerative Colitis; Pernicious Anemia; Hashimoto Thyroiditis; Rheumatoid Arthritis

Study type: Observational

Funder types: Other

Identifiers

NCT03941184

19-002489

Details and patient eligibility

About

This case control study aims to determine whether spontaneous coronary artery dissection (SCAD) is associated with autoimmune diseases and to update the incidence of SCAD in a population-based cohort.

Enrollment: 114 patients

Sex: All

Ages: 18 to 110 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults age 18 to 110
• Residence in Olmsted County. Note: if sufficient numbers cannot be reached using only Olmsted County, will expand to the 27-county region.

Exclusion criteria

• None

Trial design

114 participants in 2 patient groups

SCAD cases

Description:

SCAD cases will be identified based on presence of at least one diagnosis code for SCAD followed by manual verification by a trained individual, OR, inclusion in the previously validated SCAD cohort (Tweet 2012).

Controls without SCAD

Description:

Potential controls will be identified based on absence of any SCAD diagnosis codes.