SporTRIA Study: A Multicentre Trial for Excretion Kinetics of Triamcinolone Acetonide Following Sport Related Intra-articular Injections in Knees; Definitions of the Washout Periods

Central Hospital, Nancy, France

Status: Enrolling

Conditions: Glucocorticoids; Doping in Sport

Treatments: Drug: knee intra-articular infiltration with Triamcinolone acetonide

Study type: Interventional

Funder types: Other

Identifiers

NCT04574232

2020-A01448-31

Details and patient eligibility

About

Intra-articular and peri-articular glucocorticoid (GC) injections are common in sports medicine. However, from 1st January 2022, all injectable GC routes (including intra-articular administration (IA)) will be prohibited in-competition by World Anti-Doping Agency (WADA). Due to these rules, an IA GC treatment out-of-competition could result in an adverse analytical finding (AAF) in-competition if the washout period is not clearly defined. The aim of this study is to determine the urinary excretion profile of triamcinolone acetonide following IA to help in the definition of the washout periods.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Sports practice at least 4h / week
• No comorbidities against indicating intra-articular knee injection
• Subject with a knee disease requiring intra-articular injection of GCs

Exclusion criteria

• Subject with glucocorticoid (GC) allergy or GC medical contraindication
• Pregnant women or women of childbearing potential without effective contraception
• Washout period of all injectable routes and systemic use of GCs less than 3 months

Trial design

Primary purpose: Screening

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

athletic subjects

Other group

Description:

athletic subjects who may need intra-articular knee infiltration

Treatment:

Drug: knee intra-articular infiltration with Triamcinolone acetonide