Spot Urinary Analysis to Assess Loop Diuretic Efficiency in Stable Heart Failure (DIPSTICK)

Hasselt University

Status

Terminated

Conditions

Heart Failure

Treatments

Drug: Loop diuretic downtitration

Device: Weight monitoring

Study type

Interventional

Funder types

Other

Identifiers

NCT02288819

ZOL-DIPSTICK

Details and patient eligibility

About

The primary objective of this study is to assess whether the urinary sodium/creatinine or chloride/creatinine ratio might predict successful downtitration of loop diuretics in patients with stable heart failure without clinical signs of volume overload. In addition, this study will provide information on loop diuretic efficiency and urinary electrolyte composition after intake of diuretics in stable outpatients with heart failure.

Enrollment

50 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patient has a left ventricular ejection fraction <40% or has been previously hospitalized with a primary diagnosis of heart failure
Patient receives a daily maintenance dose of loop diuretics

Exclusion criteria

Patient was hospitalized for heart failure <3 months before study inclusion
The maintenance dose of loop diuretics was changed <3 months before study inclusion
The maintenance dose of renin-angiotensin-aldosterone system blockers or beta-blocker medication was changed <3 months before study inclusion
Cardiac resynchronization therapy (CRT) was initiated <3 months before study inclusion
At the moment of inclusion, the patient has either one of the following signs of volume overload: lower leg edema +2/4, ascites, lung congestion
Patient is not able to measure his/her weight safely and correct at home