Sputum Induction by Physiotherapy and Hypertonic Saline Techniques in Asthmatic Children

University of Sao Paulo

Status: Completed

Conditions: Asthma

Treatments: Other: hypertonic saline 3%; Other: physiotherapy techniques; Other: saline + physiotherapy maneuvers

Study type: Interventional

Funder types: Other

Identifiers

NCT03136042

UNICID

Details and patient eligibility

About

This study evaluated whether physiotherapy is efficient in sputum induction and in evaluation of pulmonary inflammation in asthmatic children.

Full description

The hypertonic saline is a traditional technique to collect induced sputum, it´s safe and viable in asthmatic children, as well as the technique of sputum induction and processing has been standardized for schoolchildren.

Sometimes researchers have difficulties to obtain induced sputum in stable patients and it´s possible to use physiotherapy maneuvers to induced sputum. The manouvers are safe for adult and children asthmatics stable.

This study aimed to evaluate the effectiveness to collect induced sputum by physiotherapy maneuvers.

Enrollment: 33 patients

Sex: All

Ages: 7 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Asthmathic children used inhaled corticosteroids not associated with long-acting beta2-agonist.

Exclusion criteria

• Asthmathic children to diagnose with other chronic pulmonary pathologies (cystic fibrosis, ciliary dyskinesia, bronchiolitis obliterans, and bronchopulmonary dysplasia) before study, no significant pulmonary pathologies, incapacity to realize pulmonary function and insufficient sample.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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33 participants in 3 patient groups

physiotherapists maneuvers

Experimental group

Description:

physiotherapy techniques

Treatment:

Other: physiotherapy techniques

hypertonic saline 3%

Active Comparator group

Description:

four nebulizations with 3% hypertonic saline.

Treatment:

Other: hypertonic saline 3%

saline + physiotherapy maneuvers

Active Comparator group

Description:

1 nebulizations + physiotherapy techniques

Treatment:

Other: saline + physiotherapy maneuvers