Sputum Validation for the Molecular Diagnosis of Respiratory Viral Infections in Cystic Fibrosis (EXPIRE)

R

Regional University Hospital Center (CHRU)

Status

Completed

Conditions

Cystic Fibrosis
Respiratory Infection

Study type

Observational

Funder types

Other

Identifiers

NCT03684759
EXPIRE

Details and patient eligibility

About

The aim of this pilot study is to demonstrate the feasibility of viral biomolecular diagnosis in sputum compared to nasopharyngeal swab in cystic fibrosis acute respiratory infection.

Full description

In cystic fibrosis (CF), patients face polymicrobial airway infections. Besides bacteria, viruses are now also considered as important agents in lung function deterioration. No strategy has been established on the optimal sampling for respiratory viral molecular diagnostic in CF. Nasopharyngeal swabs (NP) are recommended for respiratory viral screening in non-CF patients but are invasive and sometimes painful for patients. As sputa are non invasive and collected for bacterial monitoring in CF patients they could represent a convenient alternative to NP swabs. This study's aim is to define whether viral screening give concordant results between sputa and NP swabs.

Enrollment

30 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Participant with Cystic Fibrosis
  • Participant able to expectorate
  • Participant with sign of acute respiratory infection

Exclusion criteria

  • participant not able to expectorate
  • patient refusing to participate

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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