SREBP1 as a Potential Biomarker Promotes Cell Proliferation and Invasion in Thyroid Cancer

People's Hospital of Zhengzhou University

Status: Completed

Conditions: Thyroid Cancer

Treatments: Other: pathologic

Study type: Observational

Funder types: Other

Identifiers

NCT04072731

SBQLL-2016-015

Details and patient eligibility

About

In this study, the investigators detected the expression of SREBP1 in thyroid cancer tissues, explored the biological functions of SREBP1 in thyroid cancer cells.

Full description

qRT-PCR and immunohistochemistry were used to detect the expression of SREBP1 in 96 pairs thyroid cancer tissues and the adjacent normal tissues. The following methods, including the MTS, colony-forming assay, flow cytometry and hoechst staining were used to detect the biological function of thyroid cancer cells based on SREBP1 interference or not.

Enrollment: 140 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Clinical diagnosis of thyroid cancer Reciving thyroidectomy surgery No experience of radiation therapy Nice treatment compliance and follow-up regularly

Exclusion criteria

Prior history of malignancy ; Radiotherapy history, chemotherapy history; Serious concomitant diseases ; Chronic renal insufficiency and liver dysfunction

Trial design

140 participants in 2 patient groups

thyroid cancer

Description:

the thyroid cancer was determined by the the Pathology Department based on the pathological evidence.

Treatment:

Other: pathologic

the adjacent thyroid tissues

Description:

the adjacent thyroid tissues was collected from the tissue that 3 centimeters from the thyroid cancer.

Treatment:

Other: pathologic