ST Elevation in Acute Chest Pain; Could Measurement of Lipoprotein-associated Phospholipase A2 (Lp-PLA2) be Helpful to the Clinician?

Alexhander Izhaki

Status: Completed

Conditions: Acute Chest Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT01041339

0075-09-WOMC

Details and patient eligibility

About

A blood test (2-3 cc peripheral venous blood) drawn /used from already available required lab tests to distinguish between pericarditis accompanied with electrocardiogram (ECG) signs mimicking infarction. A test of clinical potential if proven to be able to support either origin of acute chest pain etiology.

Full description

Too many times young patients presenting with acute chest pain are referred to invasive angiography or treated with anticoagulation therapy a measure of detrimental effect in those inflicted with acute pericarditis.

A simple blood test (the PLAC test) may have some value in aiding rapid diagnosis saving need for cath.

Enrollment: 40 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• acute chest pain
• acute ST elevation
• elevated troponin I

Exclusion criteria

• patients with recent (> 24 hour chest pain) myocardial infarction
• refusing to provide blood samples

Trial design

40 participants in 2 patient groups

acute chest pain ST elevation

Description:

patients admitted with acute chest pain sharing ST elevation in ER-ECG and elevated troponin

controls

Description:

asymptomatic patients