Stability of Driving Pressure Changes During "Best Positive End Expiratory Pressure (PEEP)" Trial

The University of Alabama at Birmingham

Status: Withdrawn

Conditions: Acute Respiratory Distress Syndrome; Acute Respiratory Failure

Study type: Observational

Funder types: Other

Identifiers

NCT05958862

IRB-300010038

Details and patient eligibility

About

The goal of this study is to better understand in changes in lung compliance as indicated by driving pressure (a non-invasive marker) following changes in positive end expiratory pressure (PEEP; a standard of care ventilator parameter).

The main question it aims to answer is: The time to stability of driving pressure after a change in PEEP is made Type of study: observational study participant population/health conditions

Participants will undergo a "best PEEP trial" which is a standard intensive care intervention for patients undergoing invasive mechanical ventilation. This involves changing the patient's PEEP and looking for response in driving pressure. This will be done in a more protocolized format and data will be collected.

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients >18 years of age
• Undergoing intubation and mechanical ventilation in Medical Intensive Care Unit (MICU) or Medical Critical Care Unit (MCCU) at the University of Alabama Birmingham.

Exclusion criteria

• Prisoner
• Pregnant
• Age <18 years of age
• Intensive Care Unit (ICU) team declines participation
• Unstable oxygenation (requiring 100% FiO2 to maintain saturations greater than 90% oxygen saturation following initial PEEP titration by primary team)
• Hemodynamic instability: vasopressor requirement of >0.3 mcg/kg/min of norepinephrine or equivalent
• Pneumomediastinum
• Pneumothorax without chest tube
• Previous enrolled in trial
• Need for immediate travel out of ICU following intubation for procedures, tests

Trial design