Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT ( KETZEREI )

Universität Münster

Status: Enrolling

Conditions: Acute Kidney Injury; Critical Illness

Treatments: Other: Effluent dose of CRRT

Study type: Interventional

Funder types: Other

Identifiers

NCT06021288

AnIt23-06

Details and patient eligibility

About

Acute kidney injury (AKI) is a well-recognized complication in critically ill patients, which often leads to the necessity of mechanical kidney support (CRRT).

In current therapeutic regimes, CRRT is used to strictly prevent azotaemia. Thus recent clinical observations, as well as data from animal testing suggest a link between controlled azotaemia and faster renal recovery in AKI patients.

The aim of the study is to improve renal recovery.

Enrollment: 165 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients (age ≥18 years)
• Critically ill patients with AKI + in need of CRRT
• Written informed consent

Exclusion criteria

• Chronic dialysis dependency
• Chronic kidney disease with estimated glomerular filtration rate (eGFR) <30 ml/min/1.73m²
• severe liver cirrhosis (Child-pugh C)
• severe acidosis (pH < 7,20 at study enrolment)
• severe hyperkalaemia (> 6mmol/l)
• Pregnancy or breastfeeding
• persons held in an institution by legal or official order
• Dependency on the investigator or center

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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165 participants in 2 patient groups

Intervention Group

Experimental group

Description:

CRRT will be established with a draining dose (effluent dose) of 10-15ml/kg/h in pursuit of establishing a controlled azotaemia.

Treatment:

Other: Effluent dose of CRRT

Control Group

Active Comparator group

Description:

Standard of Care: CRRT will be established with a draining dose (effluent dose) of 25-30ml/kg/h

Treatment:

Other: Effluent dose of CRRT